The occupation cuts will cost between $10m (£6.5m) and $20m in severance pay, while the reproducing will cost in the midst of $5m and $15m, the affiliation said.
Offers in Twitter rose 2% in pre-business part exchanging taking after the announcement.
The move comes days after related promoter Jack Dorsey was acknowledged as Twitter’s ceaseless CEO.
He had served as the between time chief of the relationship for three months after Dick Costolo meandered down on 1 July.
Mr Costolo, who was CEO from 2010 to this year, had been under weight from cash related powers miserable with the association’s client progression.
In a letter to Twitter workers, Mr Dorsey stayed in contact with: “We have settled on a to an uncommon degree great choice – we plan to run separate courses with up to 336 individuals from over the affiliation.
“We are doing this with the most convincing significant admiration for every single individual.
“Twitter will propel a great attempt to deal with every person in giving liberal way out gatherings and help finding another occupation.”
Mr Dorsey told specialists: “Messages like this are consistently stacked with corporate talk so I’m going to offer it to you straight.”
He continued to organize how the Twitter had been “functioning for the duration of the day and for the duration of the night to pass on streamlined helper for Twitter, Vine and Periscope” and outlined the affiliation’s most recent change as “an in number examine the predetermination of how individuals will see what’s procedure on the plane