Sunday, December 26th, 2021

Could a “sense” DNA medication reverse antisense medication to treat blood clumps and avoid dying?

Inspectors from Isis Pharmaceuticals (Carlsbad, CA) and Prysis Biotechnologies (Pudong, Shanghai, China) have shown affirmation of-thought for utilizing a sense oligonucleotide to settle the impacts of an antisense drug, antithrombotic specialists in this novel study. The sense oligonucleotide counteractant rotated the activities of the antisense antithrombotic drug in the mouse show up and kept the draining that as a rule happens with undermining to coagulation treatment, as delineated in an article in Nucleic Acid Therapeutics, a sidekick researched diary from Mary Ann Liebert, Inc. distributers. The article is accessible free on the Nucleic Acid Therapeutics site until November 13, 2015.

Jeff Crosby, Chenguang Zhao, Hong Zhang, A. Robert MacLeod, Shuling Guo, and Brett Monia treated mice with an antisense oligonucleotide remedy wanted to cover the breaking point of liver and platelets to pass on prothrombin, a protein required for blood to coagulate. Resulting treatment with a prothrombin sense oligonucleotide cure induced an estimations subordinate inversion of the antisense drug advancement and the section of prothrombin to general levels. The researchers delineate the study format and the repercussions of their revelations in the article “Trading Antisense Oligonucleotide Activity with a Sense Oligonucleotide Antidote: Proof of Concept Targeting Prothrombin.”

“A brilliant show of the achievability of rotating the impacts of an antisense oligonucleotide in vivo by organizing a counteractant oligonucleotide,” says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children’s Hospital of Michigan, Detroit, MI. “It will be captivating to now perceive how the science can be enhanced to complete clarification to clinical attainability.”

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